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目的 分析血浆纤维蛋白原β链(FGB)与急性心肌梗死(AMI)的相关性及FGB对AMI超急性期诊断价值。方法 选取2018年2月至2021年4月期间就诊于吉林大学中日联谊医院心血管内科明确诊断为AMI的患者129例，其中超急性期患者86例，急性期患者43例；非AMI患者97例作为研究对象。收集患者血浆样本，酶联免疫吸附实验(ELISA)检测FGB浓度，Spearman相关分析FGB与实验室指标的相关性，Logistic回归分析AMI的影响因素，受试者工作特征(ROC)曲线分析FGB对AMI的诊断价值。结果 AMI超急性期组FGB浓度2.925(2.112,4.000)ng/mL,AMI急性期组FGB浓度4.980(3.501,6.400)ng/mL,对照组FGB浓度5.017(3.179,7.227)ng/mL。AMI超急性期组的FGB较AMI急性期组和对照组低，差异有统计学意义(P<0.05)。Spearman相关分析显示FGB浓度与HDL-C、RBC、HGB呈正相关(P<0.05),其相关系数分别为0.246、0.216、0.172,与TG、WBC、NEU呈负相关(P<0.05),其相关系数分别为-0.159、-0.186、-0.195。Logistic回归分析显示，血浆FGB水平降低，AMI发生风险升高(OR=0.695,P<0.05)。ROC曲线分析提示，FGB诊断AMI超急性期的最佳截断值为4.235 ng/mL,曲线下面积为0.752,敏感性和特异性分别为63.9%和81.4%。结论 AMI超急性期血浆FGB水平下降，FGB水平对AMI超急性期的诊断有一定价值。
Abstract：Objective To analyze the correlation between plasma fibrinogen beta chain(FGB) and acute myocardial infarction(AMI),and the diagnostic value of FGB in the hyperacute phase of AMI.Methods A total of 129 patients diagnosed with AMI were selected from the Department of Cardiovascular Medicine at China-Japan Union Hospital of Jilin University from February 2018 to April 2021,including 86 patients in the hyperacute phase and 43 in the acute phase, and 97 patients without AMI for the study.Plasma samples were collected, and the concentration of FGB was detected by enzyme-linked immunosorbent assay(ELISA).Spearman correlation analysis was used to analyze the correlation between FGB and other indicators.Logistic regression analysis was used to analyze the influencing factors of AMI,and the diagnostic value of FGB on AMI was analyzed by the receiver operating characteristic(ROC) curve.Results The ELISA results showed that the FGB concentration in the hyperacute phase of AMI group was 2.925(2.112,4.000) ng/mL,the FGB concentration in the acute phase of AMI group was 4.980(3.501,6.400) ng/mL,while the FGB concentration in the control group was 5.017(3.179,7.227) ng/mL.The FGB in the AMI hyperacute phase group was significantly lower than that in the AMI acute phase group and the control group, with a statistically significant difference(P<0.05).Spearman correlation analysis revealed that FGB concentration was positively correlated with HDL-C,RBC and HGB(P<0.05),with correlation coefficients of 0.246,0.216 and 0.172,respectively, while negatively correlated with TG,WBC and NEU(P<0.05),with correlation coefficients of-0.159,-0.186,and-0.195,respectively.Logistic regression analysis showed that lower plasma FGB concentration increased the risk of AMI(OR=0.695,P<0.05).ROC curve analysis suggested that the optimal cut-off value of FGB diagnosis for the hyperacute phase of AMI was 4.235ng/mL,with an area under the curve of 0.752.The sensitivity and specificity were 63.9% and 81.4%,respectively.Conclusion The plasma FGB levels in hyperacute phase of AMI decrease, and FGB levels have certain diagnostic value in the hyperacute phase of AMI.
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基本信息:
中图分类号:R542.22
引用信息:
[1]孟欣,王婷,唐文娟,等.血浆纤维蛋白原β链在急性心肌梗死诊断中的价值[J].中国实验诊断学,2025,29(12):1388-1394.
基金信息:
吉林省科技厅资助项目(20210401054YY)